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Evidence of Axonal Damage in the Early Stages of Multiple Sclerosis and Its Relevance to Disability
2001
Archives of Neurology
Objective: To assess axonal damage and its contribution to disability at different stages of multiple sclerosis (MS). Background: Recent in vivo imaging and in situ pathologic studies have demonstrated that substantial axonal damage accompanies the inflammatory lesions of MS. However, the relation of axonal damage to the duration of MS and its contribution to disability at different stages of the disease remain poorly defined. Design: We performed proton magnetic resonance spectroscopic imaging
doi:10.1001/archneur.58.1.65
pmid:11176938
fatcat:lo6nvvc6ijgrjk77ddrss7zek4