Drugs of radiological pharmacology: Quercetin

Nikolay Kolotilov
2020 Radiation Diagnostics, Radiation Therapy  
The purpose of the article is to draw attention to Quercetin as a means of radiological pharmacology within the framework of medicines' repurposing. Spectrum of pharmacological activity. Quercetin possesses anti-inflammatory (blockade of the lipoxygenase pathway of arachidonic acid metabolism, decreased synthesis of leukotrienes, serotonin and other inflammatory mediators), antioxidant, antispasmodic, diuretic, membrane stabilizing, capillary stabilizing, regenerative, estrogen-like (effect on
more » ... roline hydroxylase, inhibition of tumor necrosis factor and synthesis of interleukins), immunomodulatory, anticataractogenic, antisclerotic, angioprotective, antiviral (against influenza viruses), antitumor, proosteoclastic, gastroprotective, actoprotective action. Quercetin exhibits antiulcer action associated with the anti-inflammatory drugs, and also has a radioprotective activity (after X-ray and gamma irradiation). The cardioprotective properties of Quercetin are conditioned by an increase in the energy supply of cardiomyocytes due to its antioxidant effect and an improvement in blood circulation. Quercetin influences bone remodeling processes. Quercetin is able to normalize blood pressure and stimulate the release of insulin, accelerate platelet aggregation, and inhibit thromboxane synthesis. Key Words: Quercetin, radioprotector, senolytic effect, dietary supplement.
doi:10.37336/2707-0700-2020-2-7 fatcat:dzpqlocbarga3kilj4r2ajojuq