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BACH1 Is a Specific Repressor ofHMOX1That Is Inactivated by Arsenite
2008
Journal of Biological Chemistry
Intracellular heme is a redox active molecule that can be detrimental to cells at high concentrations or under oxidizing conditions. To prevent accumulation, the inducible enzyme heme oxygenase-1 (HMOX1) catalyzes degradation of heme. In the absence of elevated intracellular heme or oxidative stress, the basic region leucine zipper transcriptional regulator BACH1 binds HMOX1 antioxidant response elements and represses transcription. Conversely, increased intracellular heme or sulfhydryl
doi:10.1074/jbc.m801784200
pmid:18550526
pmcid:PMC2504887
fatcat:hfiixgdjczf4dmqmzfaxi3qzca