Introduction:Normal pregnancy is a state of physiological stress in which there is increased production of free radicals and increased lipid peroxidation towards the end of pregnancy and in parallel, total antioxidant capacity gradually increases leading to an oxidative balance maintained throughout the pregnancy but in pre-eclampsia there is a biochemical imbalance with increase in lipid peroxidation and deficient antioxidant defenses. Aim Of Study: The present study is undertaken to estimate

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... erum levels of MDA, PARAOXONASE, Total Cholesterol, LDL-C, HDL-C, Triglycerides in normal pregnant women and pregnant women with Preeclampsia and to evaluate the correlation between MDA and PARAOXONASE and to evaluate MDA as a marker of Lipid Peroxidation. Materials And Methods: A case control study was done including 50 pregnant women with Pre-eclampsia as cases and 50 age matched normal pregnant women as controls. Serum lipid profile was estimated and serum MDA level was estimated by (NADIGER et al method), PARAOXONASE was estimated by (MACKNESS AND MACKNESS method). Results: TC, LDL-C, TG and MDA levels were significantly increased and HDL-C and PARAOXONASE levels were significantly decreased in cases compared to controls. Pearson's correlation analysis showed a significant negative correlation between serum levels of MDA and PARAOXONASE and a significant positive correlation between serum levels of PARAOXONASE and HDL-C and significant negative correlation between serum levels of PARAOXONASE and LDL-C in cases. Summary And Conclusion: In PRE-ECLAMPSIA there is altered lipid metabolism with increased lipid perosidation and decreased antioxidants. LDL is more susceptible to oxidation, it redily gets oxidized by MDA, to form oxidized LDL which is taken up by macrophages via scavenger receptors and form FOAM cells which in turn results in atherogenesis. Ox-LDL particles might be involved in vascular endothelial damage. Hence it may be concluded that endothelial cell damage and dysfunction as the major cause of PRE-ECLAMPSIA.