Structural and functional neuroimaging in Klinefelter (47,XXY) syndrome: A review of the literature and preliminary results from a functional magnetic resonance imaging study of language

Kyle Steinman, Judith Ross, Song Lai, Allan Reiss, Fumiko Hoeft
2009 Developmental Disabilities Research Reviews  
Klinefelter (47, XXY) syndrome (KS), the most common form of sex-chromosomal aneuploidy, is characterized by physical, endocrinologic, and reproductive abnormalities. Individuals with KS also exhibit a cognitive/behavioral phenotype characterized by language and language-based learning disabilities and executive and attentional dysfunction in the setting of normal general intelligence. The underlying neurobiologic mechanisms are just now beginning to be elucidated through structural and
more » ... al neuroimaging. Here, we review the literature of structural and functional neural findings in KS identified by neuroimaging and present preliminary results from a functional magnetic resonance imaging study examining brain activity during a verb generation task in KS.
doi:10.1002/ddrr.84 pmid:20014370 pmcid:PMC2876340 fatcat:q4eevket7za23m6nwzupt3ocqa