The purpose of this study is to investigate the relationship between the adoption of a mobile-based personal health record (PHR) system and hospital profitability. Understanding the relationship between a hospital's profitability and the adoption of a mobile-based PHR system will provide insight into the characteristics of adopters of mobile-based PHR systems. Methods: Logistic regression analysis was employed to examine the association between hospital profitability and hospital adoption of

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... ilebased PHR providing the following functions: (1) booking, (2) past or current prescription information, and (3) test results. Results: We observed a statistically significant association between prescription information service and hospital profitability (operating margin: odds ratio [OR], 0.93; 95% confidence interval [CI], 0.89-0.96; net profit to gross revenues: OR, 0.94; 95% CI, 0.89-0.99). Also, there was a statistically significant relationship between test result service and hospital profitability (operating margin: OR, 0.94; 95% CI, 0.90-0.98; net profit to gross revenues: OR, 0.93; 95% CI, 0.88-0.98). However, we could not observe a significant association between hospital profitability and the provision of booking services. Conclusion: Further studies are warranted to confirm our findings on the inverse association between hospital profitability and the adoption of mobilebased PHR systems.