Are Microsatellite Patterns Specific for Tumor Types? A Pilot Investigation

Tiffany Haiduk, Michael Brockmann, Christoph Schmitt, Ramona-Liza Tillmann, Monika Pieper, Jessica Lüsebrink, Oliver Schildgen, Verena Schildgen
2020 Journal of Molecular Pathology  
Microsatellite testing is an emerging field of molecular pathology, as microsatellite instability (MSI) appears to be a predictive biomarker for some cancers. Although multiple studies on microsatellites have been published, recent observations suggest that the microsatellites that define instability differ between tumor entities. This assumption is confirmed by the present study that compared different MSI assays validated for colorectal cancer. Whilst all assays deliver the same MSI/MSS
more » ... for colorectal cancers, they differ for tonsillar tumors, leading to the hypothesis that MSI patterns are tumor-type specific.
doi:10.3390/jmp1010002 fatcat:226237jdkjfdvc2mgmgb46tlei