P300 brain potential among workers exposed to organic solvents

Bente E. Moen, Trond Riise, Knut Rasmus Kyvik
2009 Norsk Epidemiologi  
<strong><span style="font-family: TimesNewRomanPS-BoldMT;"><font face="TimesNewRomanPS-BoldMT"><p align="left"> </p></font></span><p align="left"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">S</span></span><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">UMMARY</span></span></p></strong><span
more » ... pan style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">The P300 component of the auditory event-related brain potential was examined in a group of 11</p><p align="left">workers exposed to low levels of organic solvents in a paint factory and 11 unexposed controls before</p><p align="left">and after 3 weeks of summer vacation. The P300 latency time was found to be prolonged among the</p><p align="left">exposed workers compared to the reference group before the summer vacation, and to be significantly</p><p align="left">longer before the vacation than after in the exposed group.</p><p align="left">The P300 component was also examined in a group of 85 seamen from chemical tankers, experiencing</p><p align="left">peak exposures to organic solvents. They were compared to a reference group of unexposed</p><p align="left">seamen. Comparing these two groups, no difference was found in the P300 latency time. No relationship</p><p align="left">between the P300 latency time and exposure was found in a multiple regression analysis, including</p><p align="left">the variables age, alcohol consumption, smoking and cerebral concussions.</p><p align="left">The study indicates the occurrence of an acute biological effect in the nervous system related to</p><p align="left">organic solvent exposure, expressed by prolonged P300 latency time. This was found at very low</p><p>exposure levels and should be studied further.</p></span></span>
doi:10.5324/nje.v9i1.439 fatcat:tyeil7h4hfbgxcnjmlfoi7hjfy