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Postischemic Brain Injury Is Exacerbated in Mice Lacking the Kinin B2 Receptor
Kallikrein cleaves low molecular weight kininogen to generate vasoactive kinins, which bind to the kinin B2 receptor, triggering a host of biological effects. Kallikrein gene delivery has been shown previously to reduce ischemia/reperfusioninduced cerebral infarction. In this study, we tested the hypothesis that the kinin B2 receptor plays a protective role in ischemic brain injury using kinin B2 receptor gene knockout (B2R-KO) mice subjected to middle cerebral artery occlusion (MCAO). Thedoi:10.1161/01.hyp.0000214867.35632.0e pmid:16534002 fatcat:ckkzipknnberjmxrqyactdsvw4