PROTON MAGNETIC RESONANCE SPECTROSCOPY STUDY IN FRONTAL WHITE MATTER OF PATIENT WITH MAJOR DEPRESSIVE DISORDER
Journal of Evidence Based Medicine and Healthcare
BACKGROUND Depression is one of the major problems of modern society and 350 million people worldwide are suffering from MDD. The purpose of this study was to examine the biochemical characteristics of the bilateral frontal white matter of first-episode, treatment-naive, non-late-life adult patients with MDD and healthy controls by using single-voxel 1H MRS. METHODS We included 45 MDD patients (24 male and 21 female), 20 healthy controls (12 males and 8 females). There were no significant
... o significant differences in sex, age, and education status between the MDD group and the healthy control group. MRS scanning was performed on both the control and patient groups. RESULTS Study showed the means of the metabolite ratio in the bilateral frontal white matter in major depressive patients and healthy controls the NAA/Cr and Choline/Cr ratio was found to be significantly decreased in major depressive disorder patients compared with the healthy control subjects. Furthermore, there was no significant correlation between the metabolite ration and HDRS score or the illness duration. CONCLUSIONS Findings suggest that the biochemical abnormalities in prefrontal white matter, especially in the left dorsolateral white matter, may occur early in the course of MDD and may be related to the neuropathology of depression. KEYWORDS Proton Magnetic Resonance Spectroscopy, Frontal White Matter, Major Depressive Disorder. HOW TO CITE THIS ARTICLE: Singh H, Verma V, Modi V, et al. Proton magnetic resonance spectroscopy study in frontal white matter of patient with major depressive disorder.