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Identification of Potential Inhibitors of Zika Virus NS5 RNA-Dependent RNA Polymerase Through Virtual Screening and Molecular Dynamic Simulations
2020
Saudi Pharmaceutical Journal
Zika virus (ZIKV) is one of the mosquito borne flavivirus with several outbreaks in past few years in tropical and subtropical regions. The non-structural proteins of flaviviruses are suitable active targets for inhibitory drugs due to their role in pathogenicity. In ZIKV, the non-structural protein 5 (NS5) RNA-Dependent RNA polymerase replicates its genome. Here we have performed virtual screening to identify suitable ligands that can potentially halt the ZIKV NS5 RNA dependent RNA polymerase
doi:10.1016/j.jsps.2020.10.005
pmid:33424251
pmcid:PMC7783101
fatcat:nglvkij33ncnde6ol4u3kbbtyi