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We propose a complete methodology to develop custom monofocal Intraocular Lens (IOL) designs and evaluate their performance on-axis based on an analytical formulation. The analytical formulation was based on Gaussian and primary aberration theory applied to custom (individual biometric data) and realistic (multilayer cornea and thick IOL) pseudoaphakic eye models. Gradient-based optimization algorithms were performed to search for optimal designs. Using two parameters, the best design wasdoi:10.1364/oe.15.008576 pmid:19547191 fatcat:dsdufas3rvejxircc3a5egyfiq