Response of Vascular Endothelial Growth Factor and Endostatin to a Session Activity before and after a Period of L-Arginine Supplementation in Active Men

Morteza Motahari, Rad, Seyyed Reza, Attarzadeh Hosseini
2017 Arak Medical University Journal (AMUJ)   unpublished
The aim of this study was to investigate the response of the most important angiogenic and angiostatic factors to a session activity before and after a period of L-Arginine supplementation in active men. Materials and Methods: In this practical and semi experimental study, 22 active men were selected by convenience sampling method and they were randomly assigned into supplement (n=11) and placebo (n=11) groups. Baseline levels of VEGF and endostatin were measured, then subjects participated an
more » ... xhaustive treadmill protocol in pre-test and post-test. Immediately and two hours after the protocol, 3 cc blood samples were prepared. The subjects used daily 0.1 g.kg-1 respectively taking l-arginine and placebo for 14 days. The results were analyzed at the significant level (p<0.05). Results: Immediately after exercise, the levels of VEGF and VEGF to endostatin ratio were significantly decreased in both groups compared to baseline (p≤0.05), and two hours later this change were lower than the baseline value (p≤0.05). The levels of endostatin immediately after exercise were significantly increased in both groups compared to baseline (p≤0.05) and two hours later this change were lower than the baseline value (p≤0.05). Before and after L-Arginine supplementation, the levels, of VEGF and VEGF to endostatin ratio immediately after exercise were not significant(p≥0.05). while this change in the supplementation group were significantly increased two hours after exercise (p≤0.05). There was no significant change in the levels of endostatin between two groups immediately after exercise (p≥0.05); however, these changes were significantly decreased two hours after exercise (p≤0.05). Conclusion: It seems that short-term L-arginine supplementation probably stimulate angiogenesis factors in response to exercise in active men.
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