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Pyridine Based Antitumour Compounds Acting at the Colchicine Site
2016
Current Medicinal Chemistry
Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharmacokinetic and pharmacodynamics properties. CSL have been classified according to their chemical structures and the chemical structures of the pyridine and azine containing
doi:10.2174/092986732311160420104823
pmid:27117490
fatcat:wfuurrmhyrd3ncz5fqdaape2vq