In recent years, a technique using a mass spectrometer has attracted a great deal of attention as a new identification method of microorganisms, and around 2300 systems (MALDI Biotyper: Bruker) are introduced in various fields including clinical area around the world. This method is said to be "innovative technology" in clinical microbiology, because it can quickly obtain reliability almost equivalent to the identification result by 16S rRNA analysis. Now that MALDI-TOF MS is widely recognized

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... s a microorganism identification system, the most needed in this field is application to drug resistance detection and typing. Then, we show the latest information and future possibility of how mass spectrometry technology is applied to these applications.