The human proteome project: Current state and future direction

P. Legrain, R. Aebersold, A. Archakov, A. Bairoch, K. Bala, L. Beretta, J. Bergeron, C. Borchers, G. L. Corthals, C. E. Costello, E. W. Deutsch, B. Domon (+13 others)
2011 Molecular & Cellular Proteomics  
After the successful completion of the Human Genome Project (HGP), the Human Proteome Organization (HUPO) has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 proteincoding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other
more » ... molecules, and functions at specific time points. As a general experimental strategy, HPP research groups will employ the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing HUPO initiatives and a chromosome-based protein mapping strategy, termed by guest on March 6, 2020 Downloaded from 3 C-HPP, with which many national teams are currently engaged. In addition, numerous biologically-driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents and tools for protein studies and analyses, and a stronger basis for personalized medicine. HUPO urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators. by guest on March 6, 2020 Downloaded from
doi:10.1074/mcp.o111.009993 pmid:21531903 fatcat:w4pnnvy6bzerrlw6gd2skv3j4q