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Presynaptic Modulation of the Retinogeniculate Synapse
Journal of Neuroscience
Modulatory projections from brainstem nuclei and intrinsic thalamic interneurons play a significant role in modifying sensory information as it is relayed from the thalamus to the cortex. In the lateral geniculate nucleus (LGN), neurotransmitters released from these modulatory inputs can affect the intrinsic conductances of thalamocortical relay neurons, thus altering their firing properties. Here, we show that in addition to postsynaptic effects, neuromodulators such as serotonin (5-HT) anddoi:10.1523/jneurosci.23-08-03130.2003 pmid:12716920 fatcat:7j35vr2z7jfbph2s6mtaama5oa