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Cytoskeletal structural proteins, released when cellular damage occurs, are biomarker candidates under investigation for many neurologic diseases. Among the potential markers, neurofilament light chain (NfL), expressed in neurons, and glial fibrillary acidic protein (GFAP), expressed in astrocytes, can now be measured in the serum (sNfL and sGFAP) thanks to advances in highly sensitive analytic methodologies, with strong correlation to CSF levels. 2]   Not surprisingly, levels of sGFAPdoi:10.1212/nxi.0000000000000988 pmid:33846269 fatcat:pq62ahbo55edpma7mwcvkac3qq