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This Month in Archives of General Psychiatry
Archives of General Psychiatry
S chellekens et al (page 339) studied central dopamine receptor sensitivity as an intermediate phenotype for alcohol dependence. Their findings suggest that COMT Val158Met and DRD2 Taq1A affect the intermediate phenotype of central dopamine sensitivity. These genes may confer their risk on alcohol dependence through reduced dopamine sensitivity in the prefrontal cortex and the hindbrain, respectively.doi:10.1001/archgenpsychiatry.2011.1199 fatcat:3e3mgll4rben3ge7wwc4xqx7fy