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Rats remain a major model for studying disease mechanisms and discovery, validation, and testing of new compounds to improve human health. The rat's value continues to grow as indicated by the more than 1.4 million publications (second to human) at PubMed documenting important discoveries using this model. Advanced sequencing technologies, genome modification techniques, and the development of embryonic stem cell protocols ensure the rat remains an important mammalian model for disease studies.doi:10.1093/ilar/ilw041 pmid:28838068 pmcid:PMC6057551 fatcat:35ugntkgzzc6jl3o546n7cidhy