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Elongation-Competent Pauses Govern the Fidelity of a Viral RNA-Dependent RNA Polymerase
Graphical Abstract Highlights d The RNAP elongation dynamic of dsRNA virus is captured by magnetic tweezers d Large sets of high-resolution data allow quantification of polymerase fidelity d Maximum likelihood estimation allows extraction of critical model parameters d Errors are predominantly incorporated via new error-prone catalytic pathwaydoi:10.1016/j.celrep.2015.01.031 pmid:25683720 fatcat:vyo36nulofhehbxmlajcajqk6e