A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Translational landscape and protein biogenesis demands of the early secretory pathway in Komagataella phaffii
[post]
2020
unpublished
Background: Eukaryotes use distinct networks of biogenesis factors to synthesize, fold, monitor, traffic, and secrete proteins. During heterologous expression, saturation of any of these networks may bottleneck titer and yield. To understand the flux through various routes into the early secretory pathway, we quantified the global and membrane-associated translatomes of Komagataella phaffii . Results: By coupling Ribo-seq with long-read mRNA sequencing, we generated a new annotation of
doi:10.21203/rs.3.rs-60134/v2
fatcat:o2qhdhyqafatjhmx3qirbpowcy