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AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization
Chemistry and Biology
Graphical Abstract Highlights d AICAR transformylase is targeted in cells with an ATIC homodimerization inhibitor d The resulting increase in endogenous ZMP is sufficient to activate AMPK d Downstream AMPK signaling is also activated, significantly altering cell metabolism d A mouse model of metabolic syndrome is used to show therapeutic viability Correspondence firstname.lastname@example.org In Brief Asby et al. report a new approach to AMPK activation. Using an inhibitor of AICAR transformylasedoi:10.1016/j.chembiol.2015.06.008 pmid:26144885 fatcat:z7bjunesfvcnlesxud6iedxjzm