Anaemia, renal insufficiency and cardiovascular outcome

Janet Hegarty, Robert N. Foley
2001 Nephrology, Dialysis and Transplantation  
Cellular models of cardiac hypertrophy and cardiac failure suggest that haemodynamic stresses lead to increased rates of cardiac myocyte apoptosis and ®brosis. Over the last 15 years, it has been become evident that the dramatically ampli®ed exposure of patients with renal insuf®ciency to haemodynamic stress leads to maladaptive vascular and ventricular adaptations. Anaemia and hypertension are remediable haemodynamic stresses consistently associated with left ventricular enlargement in
more » ... argement in observational studies. Observational studies and clinical trials have shown consistently that treating the established, typically severe, anaemia of end-stage renal disease (ESRD) improves outcome. It has become clear that late intervention to normalize haemoglobin in patients with ESRD and cardiomyopathy achieves little. There is considerable observational evidence to suggest that intervention in haemodynamic risk factors, such as anaemia and hypertension, should coincide with their onset, which is typically years before renal replacement therapy. The optimum target haemoglobin, and timing of intervention, remain areas of intense speculation and research effort.
doi:10.1093/ndt/16.suppl_1.102 pmid:11369834 fatcat:xsxefpxeljfwxp7g4jkfftdg2m