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Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor
Tumour necrosis factor (TNF)-induced death of oligodendrocytes, the cell type targeted in multiple sclerosis, is mediated by TNF receptor p55 (TNFR-p55). The ligation of TNFR-p55 induces several signal transduction pathways; however, the precise mechanism involved in human oligodendrocyte (hOL) death is unknown. We defined that TNF-induced death of hOLs is non-caspase dependent, as evidenced by lack of generation of caspases 8, 1 and 3 active subunits; lack of cleavage of caspases 1 and 3doi:10.1093/brain/awh627 pmid:16219674 fatcat:reielqz4rjbmnmtbb5s7cuucwa