Objective: The study was aimed to evaluate in vitro hepatoprotective activity of yellow leaf extracts of Thespesiapopulnea. Methods: Hepatoprotective activity is studied by carbon tetrachloride-induced hepato-toxicity in isolated rat hepatocytes. The biochemical parameters observed in serum were serum glutamate oxaloacetate transaminase (SGOT/AST), serum glutamate pyruvate transaminase (SGPT/ALT) levels. The extracts exhibited a dose-dependent reduction in AST, ALT levels. Results: Methanolic

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... tract was found to exhibit higher hepatoprotection. T. populnea extract was found to be antihepatotoxic at a concentration of 125 mcg with a significant decrease in ALT (P<0.001) and AST (P<0.0001). Conclusion: The results suggest that the methanolic extract has produced significant (p<0.001) hepatoprotection by decreasing the activity of serum enzymes which is comparable to that of standard drug silymarin.