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Anti-Tn-reactive immunoglobulin M might form the first line of defense against SARS-CoV-2 infection (COVID-19): A proposed immunobiological background
While the contact between SARS-CoV-2 and host results in formation of a trans-species O-glycan bridge and infection is initiated by Tn-antigen production, the pre-existing natural anti-Tn-reactive IgM becomes the first line of defense. The anti-Tn-reactive immunoglobulin M (IgM) is hypothetical identical to the nonimmune anti-A-reactive blood group isoagglutinin activity (Arend, 2017; Arend, 2022), expressed by the ancient poly- and autoreactive germline-encoded immunoglobulin M (IgM) indoi:10.6084/m9.figshare.21371088.v7 fatcat:uknbnc5livgplirev3sqwm7r7m