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Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats
2021
Toxins
The mycotoxin ochratoxin A (OTA) is a potent nephrocarcinogen, mainly in male rats. The aim of this study was to determine the time course of gene expression (GeneChip® Rat Gene 2.0 ST Array, Affymetrix) in kidney samples from male and female F344 rats, treated daily (p.o) with 0.50 mg/kg b.w. (body weight) of OTA for 7 or 21 days, and evaluate if there were differences between both sexes. After OTA treatment, there was an evolution of gene expression in the kidney over time, with more
doi:10.3390/toxins13030177
pmid:33652839
fatcat:ky5obtwtiveprgxw2h5nmnnbou