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Altered Proliferation, Synthetic Activity, and Differentiation of Cultured Human sebocytes in the Absence of Vitamin A and Their Modulation by Synthetic Retinoids
1993
Journal of Investigative Dermatology
Human sebocytes maintained in medium containing delipidized serum were studied for ultrastructural characteristics, cell proliferation, lipid synthesis, immunophenotype, and keratin expression before and after the addition of the synthetic retinoids isotretinoin and acitretin (10-8 -10-5 M). Compared to the properties of sebocytes cultured in normal sebocyte medium (1-2 X 10-7 M vitamin A), the use of delipidized serum (undetectable amounts of vitamin A) resui ted in prominent decrease of i)
doi:10.1111/1523-1747.ep12366092
pmid:8409536
fatcat:izgjr5uke5ghzjrdsls3pogpua