The soluble sperm factor that activates the egg: PLCzeta and beyond

Karl Swann
2020 Reproduction  
PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs.
doi:10.1530/rep-20-0079 pmid:32485666 fatcat:2qccwpehvbfqzfhnubsekfmlmy