A Case of Glomerular Lipidosis Accompanied by Familial Combined Hyperlipidemia and Panhypopituitarism

Tomoko ABE, Takahito KONDO, Akihiko SUZUKI, Hiroshi YAMAMOTO, Naoyoshi WATANABE, Rensuke KURODA, Yuichiro FUKAZAWA, Yoshikazu KAWAKAMI
1992 Internal medicine (Tokyo. 1992)  
This is a report of a case of glomerular lipidosis with familial combined hyperlipidemia and panhypopituitarism. A 60-yr-old woman was admitted for evaluation of hyponatremia. Admini stration of hydrocortisone normalized the level of serum Na. A pituitary hormone-stimulating test and brain computed tomography revealed panhypopituitarism with an empty sella. Glucocorticoid deficiency due to secondary hypoaldosteronism was thought to have caused the Na loss. She had been treated for thyroid
more » ... ction and hyperlipidemia with replacement of thyroid hormone and a lipid-lowering drug. Hyperlipidemia changed from type V into IIa in 4yr. Furthermore, one of her brothers and one of her sons were suspected to have type IV hyperlipidemia. Familial combined hyperlipidemia accompanied by secondary hypothyroidism was thought to have increased the levels of both total cholesterol and triglyceride. Two renal biopsies in 3 yr showed lipid deposits in the mesangial cells and indicated a positive correlation between the levels of serum lipids and lipid deposits in glomeruli, which suggested an important role of abnormal lipid metabolism in the progression of glomerular lipidosis. (Internal Medicine 31: 44-49, 1992) Key words: empty sella syndrome, hyponatremia, hypothyroidism ment of hyponatremia, was suggested (Fig. 1) .
doi:10.2169/internalmedicine.31.44 fatcat:4xxrcpzavnhnjmdmytlckbvlbu