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Mantle cell lymphoma (MCL) remains one of the more challenging sub-types of non-Hodgkin lymphoma. This entity, which is only approximately 10 years old, is characterized by response to many different chemotherapy regimens, though the duration of those responses remains often times quite short. Retreatment with second and third line combination regimens results in shorter and shorter durations of response, with the rapid emergence of a very drugresistant phenotype. Despite these oftendoi:10.1182/asheducation-2007.1.270 pmid:18024640 fatcat:cflrsue6bnfl3lbytemwbxqjwi