Objective: To investigate the clinical significance of dynamic monitoring of VEGF, SECAD, HCY and TNF-α in serum levels in patients with gastric cancer. Methods: A total of 94 patients with gastric cancer treated in our hospital from February 2013 to September 2014 were selected as the subjects. Sixty healthy subjects were selected as control group. VEGF, SE-CAD, HCY and TNF-α in serum levels were measured by cyclic enzyme method and enzyme-linked immunosorbent assay (ELISA). The correlation

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... ween the serum index and prognosis was analyzed. Results: The levels of Hcy, VEGF, SE-CAD and TNF-α in serum of gastric cancer group were significantly higher than those in control group. 1 month after surgery, levels of Hcy, VEGF, SE-CAD and TNF-α were still higher than those in control group. 3 months after surgery, Hcy, SE-CAD, TNF-α levels reached to the normal range, while VEGF was still higher than the normal range. The levels of Hcy, VEGF, SE-CAD and TNF-α in relapse group were significantly higher than those in non-recurrence group after 3 years of follow-up. Conclusion: The results show that the changes of serum Hcy, VEGF, SECAD and TNF-α level in patients with gastric cancer before and after operation were related to the disease condition and prognosis. The dynamic monitoring of the changes of Hcy, VEGF and TNF-α was helpful to the observation and prognosis.