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On the transition coordinate for protein folding
1998
Journal of Chemical Physics
To understand the kinetics of protein folding, we introduce the concept of a "transition coordinate" which is defined to be the coordinate along which the system progresses most slowly. As a practical implementation of this concept, we define the transmission coefficient for any conformation to be the probability for a chain with the given conformation to fold before it unfolds. Since the transmission coefficient can serve as the best possible measure of kinetic distance for a system, we
doi:10.1063/1.475393
fatcat:rfnex36gxzdvpmr5oqnqkmtbwq