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A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus
2003
Development
The molecular basis of the antagonism between cellular proliferation and differentiation is poorly understood. We have investigated the role of the cyclin-dependent kinase inhibitor p27 Xic1 in the co-ordination of cell cycle exit and differentiation during early myogenesis in vivo using Xenopus embryos. In this report, we demonstrate that p27 Xic1 is highly expressed in the developing myotome, that ablation of p27 Xic1 protein prevents muscle differentiation and that p27 Xic1 synergizes with
doi:10.1242/dev.00180
pmid:12441292
fatcat:bdmatrpmbbcszjpxewl52hh4ci