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Motivation:High-throughput conformation capture experiments such as Hi-C provide genome-widemaps of chromatin interactions, enabling life scientists to investigate the role of the three-dimensionalstructure of genomes in gene regulation and other essential cellular functions. A fundamental problem inthe analysis of Hi-C data is how to compare two contact maps derived from Hi-C experiments. Detecting similarities and differences between contact maps is critical in evaluating the reproducibilitydoi:10.1101/540708 fatcat:hbmcrt2phzb5ne3ynrzy2uig6m