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Efficacy and safety of medium- and high-dose diltiazem alone and in combination with digoxin for control of heart rate at rest and during exercise in patients with chronic atrial fibrillation
We evaluated the efficacy and the safety of medium-(240 mg/day) and high-dose (360 mg/day) diltiazem alone and in combination with digoxin when used for control of heart rate in 12 patients with chronic atrial fibrillation. Medium-dose diltiazem was comparable to therapeutic dose of digoxin at rest (88 ± 19 vs 86 + 12 beats/min) but superior during peak exercise (154 23 vs 170 + 20 beats/min; p < .05). High-dose diltiazem resulted in better control of heart rate than digoxin both at rest (79 17doi:10.1161/01.cir.73.2.316 pmid:3943166 fatcat:53sfha4purbohghlmx6fo7wlee