INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN 2230-8407 NEBULIZATION THERAPY-A NOVEL APPROACH TO DRUG DELIVERY SYSTEM IN AYURVEDA
RESEARCH JOURNAL OF PHARMACY
Several route of administration of drug have not only been described in Ayurvedic texts but also practiced for several millennia. Depending upon physical property of the drug it can be rubbed on the skin like lotion or it can be instilled in the form of drops like nasal (nasya)/ ear (karnapurana) drop etc. It can be swallowed in the form of tablets and also it can be injected directly into the bloodstream. Similarly the medicines can also be administered through nasal route using nebulization
... sing nebulization technique or through meter dose inhalation. The process of Nebulization involves a suspension of fine vaporized liquid droplets-otherwise known as aerosol-to administer fluids, oxygen and liquid medication directly to the respiratory system. Nebulizers are commonly used for treatment of cystic fibrosis, asthma, COPD and other respiratory diseases. Breakthroughs in the treatment of Asthma came in light with the introduction of Inhalation therapy (Nebulization / Aerosol mode of drug administration) in the conventional medicine. There are several plus points for through-the-lung delivery of medication. The lungs have a large surface area, so that absorption is fast and ample. Lungs are quite tolerant to foreign substances like powders of tobacco, smoke, and fragrances of a hundred types by common men. Lungs are much more permeable than skin, nasal mucosa or the gastro-intestinal tract. This mode of administration proves to be highly beneficial in saving life in acute life threatening condition such as "Status Asthmatics". But wide range of toxic side effects of modern medicine confines its use as permanent remedy. Administration of drug through nasal route is highly prevalent also in Ayurveda. Since ancient time Acharays very well knew the importance and effectiveness of this route as they had said that"Nasa hi Shirsodvaram". There are numerous variety of drugs mentioned in Ayurvedic text which can be administered through Nasal route, namely Nasya and Dhumrapana.There is no direct evidence that drug given through Nasya and Dhumrapana acts similar to that given through Nebulization technique. According to the demand of time Ayurvedic science also requires some modification to become more permissive and harmonize with ever-increasing diseases and their various presentations. Thus there is need to search Ayuurvedic formulations to be used for inhalation which are as effective as modern inhalation therapy and have least side effect and that can be useful in emergency condition. The clinical study was planned in two parts. The first part deals with preparation of drug, its standardization and antimicrobial study and second part deals with assessment of its efficacy in acute attack of Bronchial Asthma, and its comparison with the efficacy of modern medicine. The paper will discuss the method and material use for the preparation of Ayurvedic Nebulizer drug and its standardization.