HEPATIC AND INTESTINAL CHANGES IN RATS TREATED WITH T-0126, A MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) INHIBITOR

MIYAZAKI, Satoko MIWA, Hirohiko KODAMA, Harutami YAMADA, Koichi NAGATA, Wataru TORIUMI, Kazuyuki KITAMURA, Eisuke KUME
2007 Journal of Toxicological Sciences  
In the present study, we investigated the potential toxic effects of 2-week oral treatment with T-0126, a novel microsomal triglyceride transfer protein (MTP) inhibitor, on the liver and intestine in male and female rats. Administration of T-0126 decreased serum lipids and resulted in fat accumulation in the liver and the small intestine. In addition, slight changes in the liver, including an increase in serum aminotransferase (AST and ALT) activity, presence of focal inflammatory lesions, and
more » ... rolongation of PT and APTT were observed after treatment with T-0126. These changes may be related to a mechanism based on malabsorption of fat, fat-soluble antioxidants, and vitamin K, although we cannot exclude other potential mechanisms such as direct cytotoxicity of T-0126.
doi:10.2131/jts.32.161 pmid:17538240 fatcat:dnbsn7okqrc7fi5muuqjmckt2a