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Acetylation-Dependent Binding Analysis of the Yeast Gcn5 Bromodomain Protein
2008
American journal of undergraduate research
The 439 amino acid yeast Gcn5 protein contains a C-terminal bromodomain, which is required for SAGA (Spt-Ada-Gcn5-Acetyltransferase) mediated nucleosomal acetylation and transcriptional coactivation. Bromodomains are acetyl-lysine binding modules found in many chromatin binding proteins and histone acetyltransferases. Recently, both in vivo and in vitro studies indicate that bromodomains are able to discriminate the acetylation state of lysine side-chains within histone proteins. Here, the
doi:10.33697/ajur.2008.009
fatcat:yuhvlvxzlzdczcxde576a6zd6a