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In eukaryotes, biosynthesis of many extracellular matrix glycans occurs in the Golgi apparatus. These proteins include glycosyltransferases, modifying enzymes and nucleotide-sugar conversion enzymes, many of which possess a type II membrane topology. Growing evidence indicates that both the function and Golgi localization of many of these proteins are regulated through protein-protein interactions (PPIs). Given the essential nature and conservation of extracellular matrix polysaccharides, it isdoi:10.1101/2020.02.03.932111 fatcat:y2gqvxn6mfbmjf5my5vqoiqmme