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High sodium chloride intake decreases betaine-homocysteineS-methyltransferase expression in guinea pig liver and kidney
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
Delgado-Reyes, Cassandra V., and Timothy A. Garrow. High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. cysteine S-methyltransferase (BHMT) is the only enzyme known to catabolize betaine. In addition to being a substrate for BHMT, betaine also functions as an osmoprotectant that accumulates in the kidney medulla under conditions of high extracellular osmolarity. The mechanisms that regulate the partitioning of betaine betweendoi:10.1152/ajpregu.00406.2004 pmid:15331385 fatcat:4u3bobdhxfddjhx4f6kpoczykm