Suppressed levels of growth hormone and insulin-like growth factor-1 during successful pregnancy in persistent acromegaly

Akira Shimatsu, Takeshi Usui, Tetsuya Tagami, Hideshi Kuzuya, Jun A. Takahashi
2010 Endocrine journal  
Pregnancy is a rather rare event in acromegalic women because fertility is often reduced during active disease [1, 2] . Previous reports of pregnancy in acromegalic patients [3, 4] showed that pituitary growth hormone (GH) levels were unaffected and the levels of serum insulin-like growth factor (IGF)-1 were elevated by increased placental GH variant during the second and third trimesters. We report here a case of persistent acromegaly that showed suppressed levels of GH and IGF-1 during
more » ... IGF-1 during pregnancy. case report The patient had demonstrated amenorrhea, body weight gain and progressive enlargement of the hands and feet since the age of 31 after a normal pregnancy and delivery. At the age of 36, she was examined for suspected acromegaly. Mean basal GH levels were 44.7ng/ mL, which decreased to 28.8ng/mL during an oral glu-abstract. Pregnancy is a rather rare event in acromegaly because fertility is often reduced during active disease. Previous reports of pregnancy in acromegalic patients showed that the pituitary growth hormone (GH) level was unaffected and the insulin-like growth factor (IGF)-1 level was elevated during the second and third trimesters. We describe here a case of persistent acromegaly that showed suppressed levels of GH and IGF-1 during pregnancy. The suppression of GH secretion and IGF-1 may be due to increased estrogen or other factors circulating in mid-to late pregnancy.
doi:10.1507/endocrj.k10e-069 pmid:20371983 fatcat:p7yekcutifapxfypj7xpk4nocm