Dual-Chamber Technology: Safe and Convenient Drug Delivery for Lyophilized Biologics

John Moore
2015 Journal of mucopolysaccharidosis and rare disease  
Introduction Traditional versus dual-chamber technology Traditionally, users have received lyophilized drug products in a vial (Fig. 1) . To administer it, the user meters the diluent into a syringe and then adds the diluent to the lyophilized vial. Next, the reconstituted drug is withdrawn from the vial and, after chang ing the needle, administered to the patient. This process requires careful measuring, manual dexterity, and numerous steps. It is unwieldy for medical professionals in the
more » ... c and especially for patients and their caregivers who selfadminister in nonclinical settings. Dualchamber technology is an allinone closed system. The lyophilized drug resides in one chamber; the liquid resides in the other (Fig. 2) . Immediately prior to administration, in a few simple steps, the diluent is pushed through a channel between the two chambers to reconstitute the drug, which can then be in jected. Brief Communication J Mucopolysacch Rare Dis 2015;1(1):28-30 http://dx.
doi:10.19125/jmrd.2015.1.1.28 fatcat:yaxzyydnyrau5lkoqhs7rxviru