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Characteristic Interactions with Phosphatidylinositol 4,5-Bisphosphate Determine Regulation of Kir Channels by Diverse Modulators
Journal of Biological Chemistry
The activity of specific inwardly rectifying potassium (Kir) channels is regulated by any of a number of different modulators, such as protein kinase C, G q -coupled receptor stimulation, pH, intracellular Mg 2؉ or the ␤␥subunits of G proteins. Phosphatidylinositol 4,5bisphosphate (PIP 2 ) is an essential factor for maintenance of the activity of all Kir channels. Here, we demonstrate that the strength of channel-PIP 2 interactions determines the sensitivity of Kir channels to regulation by thedoi:10.1074/jbc.m403413200 pmid:15155739 fatcat:kobed7cfbbg55i63be2alnhunu