A case study in genome-level fragment assembly

T. Chen, S. S. Skiena
2000 Bioinformatics  
Motivation: We use the fact of two teams independently sequencing the one megabase genome of Borrelia burgdorferi as an opportunity to study the accuracy of genomelevel assembly. Results: We compare the results of three different assembly programs (PHRAP, TIGR Assembler, and STROLL) on the DNA fragments used in both the Brookhaven and TIGR sequencing projects. We also describe the algorithms and data structures used in our assembly program STROLL, which was used in the Brookhaven Borrelia project.
doi:10.1093/bioinformatics/16.6.494 pmid:10980146 fatcat:s2o4cx4s3vdyro7bzq65zpirca