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Robust Estimation of Local Genetic Ancestry in Admixed Populations Using a Nonparametric Bayesian Approach
2012
Genetics
We present a new haplotype-based approach for inferring local genetic ancestry of individuals in an admixed population. Most existing approaches for local ancestry estimation ignore the latent genetic relatedness between ancestral populations and treat them as independent. In this article, we exploit such information by building an inheritance model that describes both the ancestral populations and the admixed population jointly in a unified framework. Based on an assumption that the common
doi:10.1534/genetics.112.140228
pmid:22649082
pmcid:PMC3416008
fatcat:7torgl3wrrbwjmhqzeod2vxqza