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Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han
2019
Frontiers in Immunology
Interactions of human natural killer (NK) cell inhibitory receptors with polymorphic HLA-A, -B and -C molecules educate NK cells for immune surveillance against tumor cells. The KIR A haplotype encodes a distinctive set of HLA-specific NK cell inhibiting receptors having strong influence on immunity. We observed higher frequency of KIR A homozygosity among 745 healthy Chinese Southern Han than 836 adult patients representing three types of leukemia: ALL (OR = 0.68, 95% CI = 0.52-0.89, p =
doi:10.3389/fimmu.2019.01646
pmid:31379844
pmcid:PMC6646668
fatcat:zetask5eozctxitwzknbhaeutu