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PP22. GLUCOCORTICOIDS INHIBIT APOPTOSIS OF PERIPHERAL CD1C+ DENDRITIC CELLS AND CAUSE A DOWN-REGULATION OF THE CHEMOKINE LIGANDS CCL19 AND CCL21 IN GRANULOMATOUS INFILTRATES IN TEMPORAL ARTERIES FROM PATIENTS WITH GIANT CELL ARTERITIS

A. D. Wagner, X. S. Ju, U. Wittkop, M. Peppmüller, H. Zeidler, M. Zenke
2005 Rheumatology  

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https://web.archive.org/web/20180727163000/https://watermark.silverchair.com/keh775.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAcYwggHCBgkqhkiG9w0BBwagggGzMIIBrwIBADCCAagGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMRWt0ignLBc5QZ4aPAgEQgIIBeZOOI5A14f4AG6PxAHXQ8-A8e0l5gXXEZVl3CpYVJzl5YnJKJIxaBl8JMJqPuuGPOGc1wrVJSFzcc-DV7e0wFrHfNlgVS-m19ZKdZx4dknlY9IIsRSe654SnxM9dljgxnjBE7FiP2Y1e_f_Ya0i0Sa-XSQaDuyFwVqOXOg6_qEMUShp-EN9cXj6IAM9DQ6r_7V7UUu7RcKmFiZaJAWy8QxBVfLsg6tJb69K49aTYu2lxSuEN_cBuzYHYPo2gz1nSRgCTSo4vPx46r0n6T0WOg0LtIQDoMAWYSvsd50WVequCTPskr3XAxunRCk4w27QIkU8tWmQlBAxjRuUl9iR_gjVIsr32wYecfxTSPlzyBHFwwG-UtgBDbg3RL7sD1J6Qw0_-yaR2Oyx5QkiG1nh-JpPUxnNusXtDvOiVc29DPfIo4TkTVXWFaD6Q5F27NwiqzEdr7gwaXm7539n_lOnCpvfurYYBYeu-_xmcMIAHFCUVquRxenb02AN4

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Giant cell arteritis (GCA) is a systemic granulomatous vasculitis and characterized by a prompt response to glucocorticoid therapy. Earlier studies demonstrated that dendritic cells (DC) play a major role in the pathogenesis of GCA. Due to apoptosis glucocorticoid therapy leads to a rapid, time-dependent normalization of DC in temporal arteries from GCA patients. The aim of this study was to detemine glucocorticoid regulated genes in DC of GCA patients and whether glucocorticoid influences
more » ... kines like CCL19 and CCL21 which promote DC migration from the blood stream into the granulomatous lesions.
doi:10.1093/rheumatology/keh775 fatcat:5y2xkvlrs5fgrhyg4klvf6p4jy
Citation

A. D. Wagner, X. S. Ju, U. Wittkop, M. Peppmüller, H. Zeidler, M. Zenke. "PP22. GLUCOCORTICOIDS INHIBIT APOPTOSIS OF PERIPHERAL CD1C+ DENDRITIC CELLS AND CAUSE A DOWN-REGULATION OF THE CHEMOKINE LIGANDS CCL19 AND CCL21 IN GRANULOMATOUS INFILTRATES IN TEMPORAL ARTERIES FROM PATIENTS WITH GIANT CELL ARTERITIS." Rheumatology 44.suppl_3 (2005) iii22-iii22