The present study aimed to compare early complication rates, risk factors for complications, and hospital stay lengths in patients operated on for Colorectal cancer, by using Clavien-Dindo and Common Terminology Criteria for Adverse Events (CTCAE) complication classifications. Materials and methods: 222 patients who were operated between March 2019 and June 2020 with the diagnosis of colorectal cancer and had early complications were evaluated retrospectively. Complications that developed in

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... early postoperative period were graded according to Clavien-Dindo and CTCAE classifications.The effects of demographic data, surgical technique, tumor location, neoadjuvant chemoradiotherapy history, preoperative transfusion history, urgency of the operation, additional organ resection, co-morbid diseases, pathological stage and duration of surgery on complications were compared. Results: According to the Clavien-Dindo classification, the risk of developing complications was 3 times higher in male gender, 8 times higher in open surgical intervention, and 1.7 times higher in diabetes mellitus. According to the CTCAE classification, performing liver resection in the same session increased the risk of complications 5 times, while the use of open surgical technique increased the risk 8 times. Discussion: Neither classification system is superior to the other in grading postoperative complications, and both can be used to rate surgical complications.